Martin M. Johansson

Single-cell morphological profiling reveals insights into programmed cell death

The paper compares single-cell and aggregated morphological profiling to identify programmed cell death mechanisms, finding aggregated data performs better in supervised models.

The time dimension matters: Improving mode of action classification with live-cell imaging

This paper introduces LCTP, a workflow for analyzing live-cell time series data to improve mode of action classification by capturing temporal phenotypes across compounds and cell lines.

Integrating Cell Painting and Thermal Proteome Profiling for Inference of Targets and Mechanism of Action

The paper integrates Cell Painting and Thermal Proteome Profiling to infer targets and mechanisms of action for compounds, accurately identifying known MoAs for four out of five tested compounds.

High-content morphological profiling by Cell Painting in 3D spheroids.

This paper introduces a method to apply Cell Painting to 3D spheroids for morphological profiling, detecting phenotypic changes in colorectal cancer cells under compound treatments.

Genotype-phenotype correlation analysis and therapeutic development using a patient stem cell-derived disease model of Wolfram syndrome

This study uses a patient-derived stem cell model to show that a specific WFS1 variant causes mild Wolfram syndrome, which can be treated with chemical chaperones.