Author

Stéphanie M. Guéret

AstraZeneca (United Kingdom)ORCID 0000-0001-7220-9506Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alina P. SergeevaiD· 1 shared Andreas KrämeriD· 1 shared Andrew G. BuchananiD· 1 shared Anna SigurdardottiriD· 1 shared Barry H. HonigiD· 1 shared Christopher LenziD· 1 shared D. Gareth ReesiD· 1 shared Daniel A. CannoniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

Alina P. SergeevaORCID

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2 papers

Recent·Most cited

BiochemistryACS Chemical BiologyPeer-reviewedDec 8, 2025

Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2

Christopher Lenz, Lewis Elson, Johannes Dopfer…·Stefan Knapp

This study develops peptide-based tracers for SPSB2 E3 ligase by conjugating cell-penetrating peptides to degrons, enabling efficient cellular delivery and target engagement assessment.

DOI 10.1021/acschembio.5c00702

proteomicsexperimental assay

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BiophysicsJournal of Molecular BiologyPeer-reviewedApr 24, 2024

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

Jared M. Sampson, Daniel A. Cannon, Jianxin Duan…·Lingle Wang

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

24 citations

protein structuredeep learning

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