Alina P. Sergeeva

This paper uses free energy perturbation (FEP) calculations to predict and improve the accuracy of Fc-FcRn binding energy changes due to mutations, incorporating conformational changes and coupling effects.

The paper shows Dpr4/DIP-{Theta} transneuronal interactions control branch-specific axon pruning in Drosophila mushroom body neurons, with N-Cadherin mediating this process.

The paper shows that DIPs and Dprs interact in cis within the same cells, regulating trans interactions and influencing neural development in Drosophila.

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

The paper investigates how varying affinities of CAM interactions affect synaptic targeting and neuronal survival in Drosophila, finding different affinity requirements for these processes.