Author

Carolina T. Orozco

AstraZeneca (United Kingdom)ORCID 0000-0001-7274-8833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan KennedyiD· 1 shared Christopher Lloyd· 1 shared Claudia HinzeiD· 1 shared Dalisay Giovacchini· 1 shared David Michael SansomiD· 1 shared E. A. WatersiD· 1 shared Hung‐Chang CheniD· 1 shared Kay Yeung· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alan KennedyORCID

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1 paper

Recent·Most cited

ImmunologyCell ReportsPeer-reviewedSep 1, 2024

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

Maximillian A Robinson, Alan Kennedy, Carolina T. Orozco…·David Michael Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

12 citations

humanproteomics

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