Author

Philip J. Luthert

NIHR Moorfields Biomedical Research CentreORCID 0000-0001-7276-6898Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Biophysics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Approach:deep learning· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Alexander J. E. FossiD· 2 shared Christina KieliD· 2 shared Stella PrinsiD· 2 shared Adam DiakiteiD· 1 shared Adnan TufailiD· 1 shared Alexander Clifford DayiD· 1 shared Alexander Doney· 1 shared Alicja R. RudnickaiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersSystems Biology

Alexander J. E. FossORCID

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4 papers

Recent·Most cited

BiophysicsbioRxivPreprintFeb 19, 2026

Mechanisms of macular oedema development and therapeutic response: An in-silico modelling study

Pradeep Keshavanarayana, Emmeline E. Brown, Philip J. Luthert…·Simon Walker‐Samuel

This study uses a computational model to explore how Muller cell orientation affects oedema and treatment response in Diabetic Macular Oedema.

DOI 10.64898/2026.02.17.706117

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Systems BiologyPLoS ONEPeer-reviewedJan 27, 2025

Energetics of the outer retina II: Calculation of a spatio-temporal energy budget in retinal pigment epithelium and photoreceptor cells based on quantification of cellular processes

Christina Kiel, Stella Prins, Alexander J. E. Foss, Philip J. Luthert

The paper calculates the spatio-temporal energy budget of the outer retina, showing higher ATP demand in rod-dominated areas at night and suggesting diurnal shifts in energy needs.

6 citations

humanbulk RNA-seq

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Systems BiologyPLoS ONEPeer-reviewedDec 31, 2024

Energetics of the outer retina I: Estimates of nutrient exchange and ATP generation.

Stella Prins, Christina Kiel, Alexander J. E. Foss…·Philip J. Luthert

The paper estimates ATP production rates in the outer retina and examines how nutrient exchange and rod density change with age.

2 citations

humanstatistical model

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Genetic & Genomic MedicineBioinformaticsPeer-reviewedDec 5, 2024

Autoencoder-based phenotyping of ophthalmic images highlights genetic loci influencing retinal morphology and provides epidemiologically informative biomarkers.

Panagiotis I. Sergouniotis, Adam Diakite, Kumar Gaurav…·Tomas Fitzgerald

The paper uses an autoencoder to derive retinal phenotypes from OCT images, identifies 118 genetic loci, and shows their relevance to retinal morphology and disease prediction.

18 citationstop 4%

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