Joris van der Veeken

Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories

ArchVelo models gene regulation and infers cell trajectories using scATAC-seq and scRNA-seq data, improving accuracy and identifying new differentiation trajectories in immune cells.

Caffeine-regulated molecular switches for functional control of CAR T cells in vivo

This paper develops caffeine-responsive switches for CAR T cells, showing they can be controlled by caffeine and effectively clear tumors in mice.

A unified atlas of CD8 T cell dysfunctional states in cancer and infection

The paper defines a shared differentiation trajectory of CD8 T cell dysfunction across cancer and infection using ATAC-seq and RNA-seq data from multiple studies.