Markus Schäfer

The paper uses CRISPR screens to identify regulators of immunosuppressive surface molecules in cancer cells, finding DNAJC13 as a key regulator that enhances T-cell sensitivity and tumor survival.

This paper describes the engineering of a molecular switch that controls CARs and transcription factors using an orally available drug, demonstrating tight regulation in vitro and in vivo.

This paper develops caffeine-responsive switches for CAR T cells, showing they can be controlled by caffeine and effectively clear tumors in mice.