Yuri Pritykin

This study uses prime editing to identify and characterize MutSβ inhibitors that reduce (CAG)n repeat expansion.

This study identifies PD-L2's role on dendritic cells in restraining CD8+ T cell immunity in tumors, showing distinct functions from PD-L1 and suggesting therapeutic implications for PD-L2 blockade.

The paper investigates how shared Su(Hw) binding sites between TAD boundaries affect long-distance regulation and physical interactions in Drosophila.

The paper introduces Domino, a deep learning framework that models sequence-to-function relationships to uncover the context-specific grammar of Drosophila chromatin insulation.

The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.

ArchVelo models gene regulation and infers cell trajectories using scATAC-seq and scRNA-seq data, improving accuracy and identifying new differentiation trajectories in immune cells.

The paper presents a machine learning challenge to predict gene perturbation effects on T cell differentiation, finding that feature representation from perturbational data improves performance and validating top genes experimentally.

The paper identifies distal and interchromosomal chromatin interactions in T cells using a new algorithm and links them to gene regulation through epigenomic analysis.

This paper benchmarks cell type deconvolution methods in spatial transcriptomics, finding that a simple marker gene scoring approach performs well, especially for rare cell types, and applies it to study anti-PD1 immunotherapy in a mouse model.

The paper investigates how marsupial neonates use cathelicidin antimicrobial peptides for immune protection through genomic clustering and enhancer sharing, showing their effectiveness in a sepsis model.

GuideScan2 constructs high-specificity CRISPR gRNA databases and enables design of allele-specific gRNAs, reducing off-target effects in gene essentiality screens.

This paper shows autophagy prevents cachexia by suppressing CCL2, which damages appetite-promoting neurons, leading to lethal weight loss in mice.

SCARlink predicts gene expression from chromatin accessibility in single-cell multiome data, identifies enhancers, and enables chromatin potential analysis for developmental trajectories.

The paper reports 109 non-coding CRISPR screens analyzing 13.3Mb of the genome, identifies CRE-gene links, and provides guidelines and tools for screening non-coding regulatory elements.

The paper defines a shared differentiation trajectory of CD8 T cell dysfunction across cancer and infection using ATAC-seq and RNA-seq data from multiple studies.

This paper introduces a method to identify miRNA targets in vivo using Halo-Enhanced Ago2 Pulldown and demonstrates its application in mouse models.