Joseph Robert Burgoyne

This study identifies FASN as a regulator of mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy, linking lipid metabolism to epigenetic changes and cardiac disease.

This study shows that dietary glutamine reduces H3K27me3 levels in aged mice, improving cardiac function by enhancing autophagy and metabolic health.

This study shows that targeting C42 in PKGI with urolithin A reduces diastolic dysfunction and cardiac remodeling in a mouse model of HFpEF and improves heart tissue function in humans.