Author

Ajay M. Shah

King's College LondonORCID 0000-0002-6547-0631Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ajay M. Shah1 paper

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:metabolomics· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Anna ZoccaratoiD· 2 shared Jie Su· 2 shared Joseph Robert BurgoyneiD· 2 shared Adam NabeebaccusiD· 1 shared Alison C. BreweriD· 1 shared Angeliki Ntorla· 1 shared Anne Dragøy HafstadiD· 1 shared Asjad VisnagriiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Anna ZoccaratoORCID

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4 papers

Recent·Most cited

Genome-scale modelling and stable isotope tracing reveal dynamic metabolic reprogramming in a human cardiac hypertrophy model

Catherine K Takemura-James, Katarzyna Kmiotek-Caller, Ravi A Kumar, Eliano dos Santos, Rafael R Oexner, Christina M Reumiller, Sharwari Verma, Ella Bauwens, Elisavet Kiaitsi, Celio X C Santos, Katrin Streckfuss-Boemeke, Ajay M Shah, Anna Zoccarato

The paper uses genome-scale modelling and stable isotope tracing to study metabolic changes in human cardiac hypertrophy models.

bioRxiv · Nov 9, 2026 · PreprintCell Biology

Redox-activated induction of Warburg-type metabolism in the adult heart

Youwen Yang, Adam Nabeebaccus, Olga Mikhaylichenko, Christina Maria Reumiller, Domenico Cozzetto, Asjad Visnagri, Anna Zoccarato, Min Zhang, Alison C. Brewer, Anne Dragøy Hafstad, C X C Santos, Ajay M. Shah

The paper shows NOX4 induces Warburg-type metabolic reprogramming in the healthy adult heart, balancing energy and anabolic demands through transcriptional and epigenetic mechanisms.

bioRxiv · Feb 19, 2026 · PreprintPhysiology

Dietary glutamine supplementation alleviates age-related cardiac dysfunction by reducing elevated H3K27me3

Cassy Le, Pierre Coleman, Thomas Burgoyne, Jie Su, Helen R. Warren, Ravi A. Kumar, Rafael R. Oexner, Hyunchan Ahn, Angeliki Ntorla, Célio Xavier dos Santos, Ajay M. Shah, Mauro Giacca, Elisabeth Ehler, Joseph Robert Burgoyne

This study shows that dietary glutamine reduces H3K27me3 levels in aged mice, improving cardiac function by enhancing autophagy and metabolic health.

bioRxiv · May 16, 2025 · PreprintCell Biology

Targeting C42 in PKGIα alleviates diastolic dysfunction in HFpEF

Jie Su, Min Zhang, Xiaoping Yang, Mark Holt, Janice Raabe, Friederike Cuello, Ajay M. Shah, Michael J. Shattock, Joseph Robert Burgoyne

This study shows that targeting C42 in PKGI with urolithin A reduces diastolic dysfunction and cardiac remodeling in a mouse model of HFpEF and improves heart tissue function in humans.

bioRxiv · May 9, 2025 · PreprintBiochemistry