Lucas E. Sant’Anna

This paper introduces a synthetic cytokine receptor platform that programmably polarizes macrophages to defined functional states, showing enhanced phagocytosis and tumor reduction in mice.

This paper shows how recombining signaling motifs creates a continuous spectrum of CAR T cell phenotypes, revealing trade-offs between memory, cytotoxicity, and safety.

The paper develops a polymer model integrating super-resolution imaging and epigenomic sequencing to show how epigenetic reactions shape 4D chromatin organization and influence gene expression and metastatic potential.

This paper develops hDIRECT, a platform using human-derived proteins to control cytokine activity in cell-based therapies, demonstrating orthogonalization through protease regulation.