Malika Oubaha

The paper shows that during hyaloid vessel regression in mice, endothelial cells shift from ephrin-B2 to EphB4 expression, with Notch1 deletion altering this transition and affecting apoptosis and proliferation.

This study identifies developmental senescence as a key mechanism driving hyaloid vessel regression in postnatal mice through single-cell RNA sequencing and genetic experiments.

This study identifies Notch1 as a key regulator of hyaloid vessel regression, showing it drives endothelial plasticity and detachment independent of apoptosis.