Wei Wu

SOLiD-MaP maps small molecule binding sites on RNA using photoproximity labeling, demonstrating target-selective labeling and mutational profiling to identify binding regions.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

The paper develops a bioengineered vascularized pancreatic cancer model and uses multi-omics and functional assays to reveal an immunosuppressive and therapy-resistant tumor niche.

The paper identifies extracellular vesicles as immunosuppressive factors in neuroblastoma by profiling secretomes and showing their ability to suppress T cell activation.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

This study shows that disrupting CXCR4 oligomers in lymphoid cancers reduces migration, survival signaling, and tumor growth, while sensitizing cells to venetoclax.

The paper shows MTHFD2 supports creatine synthesis in PTLD models by driving glycine production, and its loss reveals tumor-suppressive effects through metabolic epistasis.

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

This study shows that single mutations during early oncogenesis can upregulate BTN2A1, enabling Vγ9Vδ2 TCR binding, but full activation requires subsequent phosphorylation of BTN3A1.