Author

Emma Lesage

Centre National de la Recherche ScientifiqueORCID 0000-0001-7366-0171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:Hi-C· 1 Organism:human· 1

Frequent Co-Authors

Aldo S. BaderiD· 1 shared Coline ArnouldiD· 1 shared Daan NoordermeeriD· 1 shared David López MartíneziD· 1 shared Gaëlle LegubeiD· 1 shared Haiyue LiuiD· 1 shared Henriette K. M. IverseniD· 1 shared Lea H. GregerseniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Aldo S. BaderORCID

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2 papers

Recent·Most cited

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

Quentin Angelo Thomas, Liyang Wu, Emma Lesage, Henriette K. M. Iversen, David López Martínez, Smaragda Kompocholi, Haiyue Liu, Nicolás Nieto Moreno, Lea H. Gregersen

The paper shows oxidative stress causes RNAPII arrest through PARylation and DNA repair pathways, leading to transcriptional shutdown and recovery.

Nature Communications · Aug 10, 2026Peer-reviewedMolecular Biology

ATM-dependent formation of a novel chromatin compartment regulates the Response to DNA Double Strand Breaks and the biogenesis of translocations

Coline Arnould, Vincent Rocher, Aldo S. Bader, Emma Lesage, Nadine Puget, Thomas Clouaire, Raphaël Mourad, Daan Noordermeer, Martin Bushell, Gaëlle Legube

The paper identifies a novel chromatin compartment formed by ATM-dependent clustering of damaged TADs, which enhances DNA damage response but increases translocations.

bioRxiv · Nov 7, 2021 · PreprintMolecular Biology