John Reeves

The paper develops a thermodynamic model linking transcriptome organization to growth state by analyzing RNA folding free energies across cell cycle and stress adaptation.

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze epithelial and fibroblast states in hormone therapy-naive prostate cancer, identifying novel phenotypes and molecular perturbations.

This study identifies JNK pathway suppression as a driver of resistance to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer, with implications for patient stratification.