Kate Harvey

Highly resolved tumor architecture via matched spatial and nucleus transcriptomics from a single tissue section

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

Profiling of epithelial functional states and fibroblast phenotypes in hormone therapy-naive localised prostate cancer

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze epithelial and fibroblast states in hormone therapy-naive prostate cancer, identifying novel phenotypes and molecular perturbations.

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

Federated deep learning enables cancer subtyping by proteomics

ProCanFDL uses federated deep learning to subtype cancers using proteomic data while preserving privacy, achieving performance gains over local models.

snPATHO-seq: unlocking the pathology archives

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.

Single cell transcriptomics reveals molecular subtype and functional heterogeneity in models of breast cancer

This study uses single-cell transcriptomics to reveal molecular subtype and functional heterogeneity in breast cancer models, identifying subpopulations with potential clinical relevance.