Tyler M. Borrman

This study uses Optical Replication Mapping to map human DNA replication initiation sites and finds that replication initiation is stochastic and not confined to specific origins.

This study introduces liquid chromatin Hi-C to analyze chromatin interaction dynamics and finds that compartmentalization stability varies with chromatin domain type and fragment size.

This study identifies early-firing human replication origins in HeLa cells using Optical Replication Mapping, revealing that initiation occurs across broad zones rather than confined to efficient origins.