Author

Houda Belaghzal

University of Massachusetts Chan Medical School

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:Hi-C· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Job DekkeriD· 3 shared Allana Schooley· 1 shared Andrew D. StephensiD· 1 shared Betül Akgöl OksuziD· 1 shared Denis L. J. LafontaineiD· 1 shared Johan Harmen GibcusiD· 1 shared John F. MarkoiD· 1 shared Joseph R. KlimiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersGenomics

Job DekkerORCID

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3 papers

Recent·Most cited

Dynamic changes in chromosome and nuclear architecture during maturation of normal and ALS C9orf72 motor neurons

Özgün Uyan, Snehal Sambare, Marlies E. Oomen, Nicholas Wightman, Allana Schooley, Joseph R. Klim, Houda Belaghzal, Özkan Aydemir, Betül Akgöl Oksuz, Zeynep Sena AGIM USLU, Kevin C. Eggan, Robert H. Brown, Job Dekker

The paper examines changes in chromosome conformation, nuclear organization, and transcription during motor neuron maturation in control and ALS C9orf72 mutant cells, finding delayed maturation in disease models.

bioRxiv · Sep 22, 2025 · PreprintNeuroscience

Compartment-dependent chromatin interaction dynamics revealed by liquid chromatin Hi-C

Houda Belaghzal, Tyler M. Borrman, Andrew D. Stephens, Denis L. J. Lafontaine, Sergey V. Venev, Zhiping Weng, John F. Marko, Job Dekker

This study introduces liquid chromatin Hi-C to analyze chromatin interaction dynamics and finds that compartmentalization stability varies with chromatin domain type and fragment size.

Nature Genetics · Feb 11, 2021Peer-reviewedGenomics

HI-C 2.0: AN OPTIMIZED HI-C PROCEDURE FOR HIGH-RESOLUTION GENOME-WIDE MAPPING OF CHROMOSOME CONFORMATION

Houda Belaghzal, Job Dekker, Johan Harmen Gibcus

Hi-C 2.0 improves Hi-C protocol to achieve high-resolution mapping of chromatin interactions with better resolution and reduced noise.

Methods · Apr 18, 2017Peer-reviewedGenomics