HMCES corrupts replication fork stability during base excision repair in homologous recombination deficient cells
María José Peña-Gómez, Yaiza Rodríguez-Martín, Marta del Rio Oliva, Yodhara Wijesekara Hanthi, Sara Berrada, Raimundo Freire, Jean‐Yves Masson, José Carlos Reyes, Vincenzo Costanzo, Iván V. Rosado
The paper shows HMCES causes replication fork instability in HRD cells during BER of 5hmdC-derived lesions, leading to chromosomal damage and cell death.
Science Advances · Mar 26, 2025Peer-reviewedMolecular Biology