Raimundo Freire

This study identifies RNF25 as an E3 ubiquitin ligase that maintains genome integrity by modulating DNA replication, transcription, and translation through ubiquitin-mediated clearance of key proteins.

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

This study identifies nucleophagy as the mechanism by which trapped PARP1 is cleared, showing that inhibiting this process re-sensitizes PARPi-resistant cells to PARPi.

The paper shows HMCES causes replication fork instability in HRD cells during BER of 5hmdC-derived lesions, leading to chromosomal damage and cell death.

This study identifies a functional interaction between TDP-43 and USP10, showing USP10 modulates alternative splicing and can reduce TDP-43 toxicity in a mouse model of ALS and FTD.

This study evaluates four commercial anti-FLCN antibodies for immunohistochemistry in BHD-associated kidney tumors but finds none are reliably effective for routine diagnostic use.

This study shows that multiple 9-1-1 complexes are essential for meiotic DSB repair, homolog synapsis, and ATR signaling in mammals.

This study identifies ATR-dependent phosphorylation sites in mouse meiosis, revealing key targets and motifs involved in DNA repair and RNA processing during prophase I.