This study conducts a systematic review and meta-analysis of 24 studies to explore the link between viral hepatitis, hepatocellular carcinoma, and neuropsychiatric disorders, identifying immune and inflammatory mechanisms.

bioRxiv · Nov 9, 2026 · PreprintCancer Biology

HTLV-1-Induced Neuroimmunome Correlates with Disease Progression and Severity

Fernando Yuri Nery do Vale, Carlota Miranda-Solé, Adriel Leal Nóbile, Júlia Nakanishi Usuda, Dennyson Leandro M. Fonseca, Lena F. Schimke, Mauro César Cafundó Morais, Débora Gomes de Albuquerque Freitas, Anny Silva Adri, Roseane Galdioli Nava, Yohan Lucas Gonçalves Corrêa, Hugo Fernando Nery do Vale, Adriana Simizo, Niels Olsen Saraiva Câmara, Gustavo Cabral‐Miranda, , Otávio Cabral-Marques

The paper identifies a neuroimmune signature in HTLV-1 infection that correlates with disease progression and severity using bulk and single-cell transcriptomic data.

bioRxiv · Mar 12, 2026 · PreprintMolecular Biology

Dysregulation of synaptic-related genes within neuroimmune networks of peripheral blood mononuclear cells in major depressive disorder

Anny Silva Adri, Adriel Leal Nóbile, Débora Gomes de Alburquerque, Pedro Marçal Barcelos, Fernando Yuri Nery do Vale, Ian Antunes Ferreira Bahia, Paula Paccielli Freire, Roseane Galdioli Nava, Yohan Lucas Gonçalves Corrêa, Gustavo Cabral‐Miranda, Rodrigo Juliani Siqueira Dalmolin, Lena F. Schimke, Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Helder Imoto Nakaya, , Otávio Cabral-Marques

The paper identifies synaptic-related gene dysregulation in PBMCs of MDD patients, highlighting shared molecular signatures with brain regions and potential biomarkers for depression.

bioRxiv · Nov 13, 2024 · PreprintBioinformatics