Or Kakhlon

This study identifies xCT regulation pathways in colon cancer using patient-specific models and reveals potential therapeutic targets for chemotherapy resistance.

The paper analyzes RNA-seq data from CRC patients to identify SLC7A11's role in metabolic regulation and cell proliferation, linking it to clinical outcomes and therapeutic responses.

This paper shows that GSD1a patient fibroblasts retain a reversible disease phenotype in vitro, driven by epigenetic and transcriptional changes, and that a drug can reverse these effects.

This study demonstrates that 144DG11 improves survival and motor function in APBD mouse models by promoting autophagic glycogen catabolism through LAMP1 interaction.