Author

Uri Sprecher

Tel Aviv UniversityORCID 0000-0003-0284-5448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Kumudesh MishraiD· 2 shared Miguel WeiliD· 2 shared Or KakhloniD· 2 shared Alexander LossosiD· 1 shared Alexandra Eliassaf· 1 shared Alexane Cannella Miliano· 1 shared Anna DukhovnyiD· 1 shared Anna Morshina· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Kumudesh MishraORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 20, 2023

Disease-associated programming of cell memory in glycogen storage disorder type 1a

Uri Sprecher, J D’Souza, Kumudesh Mishra…·Miguel Weil

This paper shows that GSD1a patient fibroblasts retain a reversible disease phenotype in vitro, driven by epigenetic and transcriptional changes, and that a drug can reverse these effects.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 18, 2021

A new drug candidate for glycogen storage disorders enhances glycogen catabolism: Lessons from Adult Polyglucosan Body Disease models

Hilla Vaknin, Kumudesh Mishra, Jeevitha D’Souza…·Miguel Weil

This study demonstrates that 144DG11 improves survival and motor function in APBD mouse models by promoting autophagic glycogen catabolism through LAMP1 interaction.

DOI 10.1101/2021.03.18.436069

mouseproteomics

𝕏 PostBluesky