Cell BiologybioRxivPreprint
NSD2 deficiency disrupts the epigenetic landscape of cochlear hair cells to enhance ECM expression and to perturb cochlear hair cell function
Ziyi Wang, Yue Xu, Xiaojie Ma…·Li Li
This study shows that NSD2 deficiency disrupts chromatin accessibility and gene expression in cochlear hair cells, leading to increased ECM expression and hearing impairment, which can be mitigated by ECM intervention.