Author

Ningyuan Liu

Shanghai Jiao Tong UniversityORCID 0000-0002-1877-6136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Hanyu RaoiD· 4 shared Rebiguli Aji· 4 shared Wei‐Qiang GaoiD· 4 shared Wenxin Feng· 4 shared Yue Xu· 4 shared Li LiiD· 3 shared Dehuan Wang· 2 shared Wei Zhang· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCell Biology

Hanyu RaoORCID

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4 papers

Recent·Most cited

NSD2 deficiency disrupts the epigenetic landscape of cochlear hair cells to enhance ECM expression and to perturb cochlear hair cell function

Ziyi Wang, Yue Xu, Xiaojie Ma, Dehuan Wang, Wenxin Feng, Ningyuan Liu, Hanyu Rao, Wei Zhang, Rebiguli Aji, Ziwen Yu, Jiahe Li, Guoning Yu, Yazhi Xing, Wei‐Qiang Gao, Li Li

This study shows that NSD2 deficiency disrupts chromatin accessibility and gene expression in cochlear hair cells, leading to increased ECM expression and hearing impairment, which can be mitigated by ECM intervention.

bioRxiv · Sep 23, 2026 · PreprintCell Biology

NSD2 promotes cell durotaxis and drives the transition from PKD to tubulocystic renal cell carcinoma through integrin/FAK/AKT signaling

Wenxin Feng, Ningyuan Liu, Changwei Liu, Hanyu Rao, Zhuo Chen, Wei Zhang, Yue Xu, Rebiguli Aji, Ziyi Wang, Wei‐Qiang Gao, Li Li

This study shows NSD2 promotes cell durotaxis and drives the transition from PKD to TCRCC via integrin/FAK/AKT signaling, with implications for targeted therapies.

Oncogene · Jul 22, 2025Peer-reviewedCancer Biology

Histone 3 lysine 36 trimethylation by SETD2 shapes an epigenetic landscape in intestinal stem cells to orchestrate lipid metabolism and prevent cell senescence.

Yue Xu, Ziyi Wang, Wenxin Feng, Hanyu Rao, Dehuan Wang, Wei Zhang, Rebiguli Aji, Ningyuan Liu, Wei‐Qiang Gao, Li Li

This study shows that H3K36me3, catalyzed by SETD2, maintains ISC stemness by regulating lipid metabolism and preventing senescence through chromatin remodeling and metabolic intervention.

bioRxiv · Apr 9, 2025 · PreprintCell Biology

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Clinical and Translational Medicine · Dec 1, 2024Peer-reviewedCell Biology