Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins
Urszula Nowicka, Piotr Chrościcki, Karen Stroobants, Maria Sladowska, Michał Turek, Barbara Uszczyńska-Ratajczak, Rishika Kundra, Tomasz K. Goral, Michele Perni, Christopher Martin Dobson, Michele Vendruscolo, Agnieszka Chacińska
The paper shows that mitochondrial protein import defects lead to cytosolic aggregation of proteins, disrupting homeostasis and contributing to neurodegenerative disease mechanisms.
eLife · Jul 20, 2021Peer-reviewedMolecular Biology