Christopher Martin Dobson

Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains

The paper investigates the formation of amyloid loops in brain tissues and finds that protofibril flexibility, not hydrogen bonding, enables loop formation and disease-related toxicity.

Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

The paper shows that mitochondrial protein import defects lead to cytosolic aggregation of proteins, disrupting homeostasis and contributing to neurodegenerative disease mechanisms.

Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies

The paper shows that α-synuclein forms liquid droplets that mature into amyloid-rich hydrogels, suggesting Lewy body formation is linked to arrested maturation in the presence of lipids.

Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming

This paper uses Integer Programming to accurately identify A-site locations on ribosome-protected mRNA fragments from Ribo-Seq data, improving signal-to-noise ratio by utilizing a wider range of fragment sizes.