Michele Perni

This study identifies monoamine-targeting compounds that rescue neurexin-related behavioral phenotypes in C. elegans and Drosophila, with olanzapine showing broad efficacy across genetic backgrounds.

This study investigates the behavioral effects of isoform-specific NRXN1 deletions in zebrafish, showing unique and overlapping deficits in locomotion, sensorimotor behavior, and social behavior.

The paper shows that mitochondrial protein import defects lead to cytosolic aggregation of proteins, disrupting homeostasis and contributing to neurodegenerative disease mechanisms.