Agnieszka Chacińska

This study investigates the role of TCF7L2 in thalamocortical energy metabolism and its impact on social behavior, finding that its loss leads to metabolic dysregulation and social deficits.

The paper uses proteomics and lipidomics to show OCIAD1 balances mitochondrial and peroxisomal lipid metabolism by affecting lipid composition and key enzymes.

The paper identifies OMA1 protease as a key factor in resolving arrested protein import intermediates in human cells through mitochondrial membrane depolarization.

The paper analyzes protein thiol oxidation in aged yeast and creates a database for cross-species comparison of redoxome data.

The paper profiles subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish by analyzing RNA from different cellular fractions and quantifying transcriptomic changes in a chchd4a-/- mutation.

The paper shows that mitochondrial protein import defects lead to cytosolic aggregation of proteins, disrupting homeostasis and contributing to neurodegenerative disease mechanisms.

The paper shows that mitochondrial proteins are locally synthesized at synapses and incorporated into respiratory chain complexes, supporting local mitochondrial biogenesis.