Yasuyuki Kihara

The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.

The paper identifies a mechanism by which FTY720 reduces MS-like disease in an animal model through B12-TCN2-CD320 signaling in astrocytes.

The paper uses snRNA-seq to compare cell type-specific transcriptomic changes between RRMS and SPMS in non-lesioned brain regions, identifying downregulation of astrocytic sphingosine kinases in SPMS.

This study validates an anti-LPA antibody (504B3) and finds it binds non-LPA lipids, suggesting potential off-target effects.

The paper challenges claims of contamination by providing evidence of APP gencDNA insertion breakpoints in Alzheimer's disease samples and supporting the existence of somatic gene recombination.