BiochemistrybioRxivPreprint
A phytocannabinoid-sensitive phosphorylation switch converts endocannabinoids into alternative lipid GPCR activators
Anna C. Love, Yasuyuki Kihara, Hirotaka Mizuno…·Jerold J. M. Chun
The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.
DOI 10.64898/2026.09.21.753239