Author

Kristina Ushakova

Immanuel Kant Baltic Federal UniversityORCID 0000-0002-6461-7777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandre ReymondiD· 2 shared Alina A. MikhailovaiD· 2 shared Alina G. MikhailovaiD· 2 shared Evgenii O. TretiakoviD· 2 shared Ilya MazuniniD· 2 shared Irina S. GostimskayaiD· 2 shared Jacques FellayiD· 2 shared Konstantin KhrapkoiD· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Alexandre ReymondORCID

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2 papers

Recent·Most cited

Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome

Victor Shamanskiy, Alina A. Mikhailova, Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Sergey Oreshkov, Дмитрий Алексеевич Кнорре, Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski, Irina S. Gostimskaya, Valerian A. Yurov, Chia‐Wei Liou, Tsu‐Kung Lin, Wolfram S. Kunz, , Konstantin Yu. Popadin

The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.

BMC Biology · May 8, 2023Peer-reviewedGenetics

A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain.

Alina G. Mikhailova, Alina A. Mikhailova, Kristina Ushakova, Evgenii O. Tretiakov, Dmitrii Iliushchenko, Victor Shamanskiy, Andrei Iurchenko, Marianna Zazhytska, Elena Kozenkova, Evgeny M. Zdobnov, Vsevolod J. Makeev, Valerian A. Yurov, M. Tanaka, Irina S. Gostimskaya, Zoë Fleischmann, , Konstantin Yu. Popadin

The paper identifies an AH>GH substitution signature in mtDNA linked to aging and TSSS, showing higher frequency in species with longer generation lengths.

bioRxiv · Dec 3, 2021 · PreprintBioinformatics