Martin H. Schaefer

Inferring tested-but-undetected pairs from prey lists of 5,530 published interaction screens yields 97 million tested human protein pairs and 18,982,508 non-interactions (≥3 tests) for calibrating screens and predictors.

The paper identifies transcript-proximal methylation-associated regulatory sites (TMRs) by integrating RNA-seq and WGBS data, showing their enrichment in cancer and correlation with transcription.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

This study shows that power-law distributions in PPI networks can arise from study and technical biases, not biological properties.

The paper uses protein-to-mRNA ratios from human tissues to develop a codon optimizer algorithm that improves tissue-specific protein expression.

This study shows that human viruses adapt their codon usage to match the translational machinery of the tissues they infect, with SARS-CoV-2 showing improved adaptation to upper respiratory airways.

The paper examines translational efficiency across healthy and tumor tissues, finding it correlates with proliferation and specific codon usage patterns.