Alessia Loffreda

This study identifies Brl1 and Brr6 as conserved fusogens mediating membrane fusion during NPC assembly in eukaryotes.

This study investigates how NF-κB co-activation enhances p53 accumulation dynamics, impairing DNA repair and revealing a transcriptionally mediated antagonism between p53 and NF-κB.

This study shows MYC enhances TOP2A diffusion, promoting its substrate binding and chromatin engagement, thereby stimulating topoisomerase activity.

The paper shows that ribosome quality control via ZNF598 degradation helps aneuploid cells survive proteotoxic stress, with ZNF598 expression linked to tumor aneuploidy.

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

This study shows that MYC uses both non-specific and sequence-specific DNA binding to regulate transcription, with sequence-specific binding contributing to transcriptional activation.

The paper characterizes the transcriptional response to TNF-α using single-cell analysis, showing heterogeneous gene expression with prompt and sharp population-level dynamics driven by 'first responders'.