Leandro Radusky

This study identifies the structural mechanism by which Wnt7a binds to exosomes for secretion, showing it is independent of palmitoylation and involves a dilysine motif interacting with COPB2.

FrustraEvo calculates and quantifies the conservation of local energetic frustration in protein families to identify evolutionary stability and functional constraints.

The paper introduces a computational method combining molecular docking and dynamics simulations to identify key amino acids in a viral protein's Carbohydrate Recognition Domain, validated by in vitro experiments.

The paper uses protein-to-mRNA ratios from human tissues to develop a codon optimizer algorithm that improves tissue-specific protein expression.

pyFoldX enables integrative analysis of protein structures using FoldX, improving handling of multiple structures and integration with Python data analysis tools.

FrustratometeR computes local energetic frustration in protein structures, point mutants, and MD simulations for structural analysis.

VarQ assesses the functional impact of single amino acid substitutions on protein activity, folding, and interactions using curated variants.