TSC1 loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearance
Carolina Alquézar, Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy K Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth A. Dombroski, Jennifer S. Yokoyama, Ana María Cuervo, Alma L. Burlingame, Gerard D. Schellenberg, Timothy M. Miller, Bruce L. Miller, Aimee W. Kao
This study identifies TSC1 loss-of-function as a risk factor for tauopathies by promoting tau acetylation and impairing autophagy-mediated tau clearance.
bioRxiv · Nov 8, 2020 · PreprintNeuroscience