Ana María Cuervo

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

TSC1 loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearance

This study identifies TSC1 loss-of-function as a risk factor for tauopathies by promoting tau acetylation and impairing autophagy-mediated tau clearance.

Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

This study identifies p300/CBP as a regulator of tau secretion via the autophagy-lysosomal pathway, showing its role in tau propagation in tauopathies.

Farnesyl Transferase Inhibition for the Treatment of Tauopathies

Lonafarnib reduces tau pathology in a tauopathy mouse model by targeting Rhes to enhance lysosomal degradation.

C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.