Author

Elisabeth E. Mlynarski

University of PennsylvaniaORCID 0000-0002-6560-2876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:GWAS summary statistics· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:variant effect prediction· 2 Research Focus:drug response / drug discovery· 1 Research Focus:eQTL / molecular QTL mapping· 1

Frequent Co-Authors

Alexandre Amlie‐WolfiD· 3 shared Gerard D. SchellenbergiD· 3 shared Li‐San WangiD· 3 shared Beth A. DombroskiiD· 2 shared Christopher D. BrowniD· 2 shared Mitchell TangiD· 2 shared Otto ValladaresiD· 2 shared Pavel P. KuksaiD· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBioinformatics

Alexandre Amlie‐WolfORCID

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Author profile →

4 papers

Recent·Most cited

TSC1 loss-of-function increases risk for tauopathy by inducing tau acetylation and preventing autophagy-mediated tau clearance

Carolina Alquézar, Kathleen M. Schoch, Ethan G. Geier, Eliana Marisa Ramos, Aurora Scrivo, Kathy K Li, Andrea R. Argouarch, Elisabeth E. Mlynarski, Beth A. Dombroski, Jennifer S. Yokoyama, Ana María Cuervo, Alma L. Burlingame, Gerard D. Schellenberg, Timothy M. Miller, Bruce L. Miller, Aimee W. Kao

This study identifies TSC1 loss-of-function as a risk factor for tauopathies by promoting tau acetylation and impairing autophagy-mediated tau clearance.

bioRxiv · Nov 8, 2020 · PreprintNeuroscience

SparkINFERNO: A scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants

Pavel P. Kuksa, Chien‐Yueh Lee, Alexandre Amlie‐Wolf, Prabhakaran Gangadharan, Elisabeth E. Mlynarski, Yi‐Fan Chou, Han‐Jen Lin, Heather Issen Nicaretta, Emily Greenfest‐Allen, Otto Valladares, Yuk Yee Leung, Li‐San Wang

SparkINFERNO efficiently identifies causal non-coding genetic variants and their molecular mechanisms using GWAS data and functional genomics datasets.

Bioinformatics · Apr 17, 2020Peer-reviewedBioinformatics

Inferring the molecular mechanisms of noncoding Alzheimer’s disease-associated genetic variants

Alexandre Amlie‐Wolf, Mitchell Tang, Jessica Way, Beth A. Dombroski, Jiang Ming, Nicholas Vrettos, Yi‐Fan Chou, Yi Zhao, Amanda B Kuzma, Elisabeth E. Mlynarski, Yuk Yee Leung, Christopher D. Brown, Li‐San Wang, Gerard D. Schellenberg

The paper identifies enhancer dysregulation and target genes for noncoding Alzheimer's disease-associated variants using GWAS and eQTL data.

Journal of Alzheimer s Disease · Sep 24, 2019Peer-reviewedBioinformatics

INFERNO - INFERring the molecular mechanisms of NOncoding genetic variants

Alexandre Amlie‐Wolf, Mitchell Tang, Elisabeth E. Mlynarski, Pavel P. Kuksa, Otto Valladares, Živadin Katanić, Debby W. Tsuang, Christopher D. Brown, Gerard D. Schellenberg, Li‐San Wang

INFERNO integrates GWAS data with functional genomics to identify causal noncoding variants and their molecular mechanisms in schizophrenia.

Nucleic Acids Research · Jul 19, 2018Peer-reviewedBioinformatics