ImmunologybioRxivPreprint
Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells
Alexandra Boegli, Elliott M. Bernard, Louise Lacante…·Petr Brož
This study shows that NLRP6 inflammasome activation in human intestinal epithelial cells occurs due to endolysosomal damage from pathogens or sterile triggers, leading to pyroptosis.
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