Petr Brož

Genome-wide CRISPRi maps pneumococcal attachment and intracellular survival during single infection and Influenza co-infection

This study uses CRISPRi to identify pneumococcal genes critical for attachment and survival during single infection and influenza co-infection, revealing key metabolic and structural dependencies.

NINJ1 is a restriction factor for HSV-1 in mouse macrophages

This study shows that NINJ1 restricts HSV-1 entry in mouse macrophages, reducing viral infection and associated inflammation.

The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death

This study identifies that the unique lipopolysaccharide (LPS) of Salmonella Typhimurium ST313 reduces pyroptosis and inflammasome activation in human macrophages, contributing to its pathogenicity.

Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

This study identifies cardiolipin as a selective inhibitor of caspase 4/11 that prevents LPS-induced inflammation without affecting caspase-1, offering a potential therapeutic for Gram-negative sepsis.

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

This study shows that NLRP6 inflammasome activation in human intestinal epithelial cells occurs due to endolysosomal damage from pathogens or sterile triggers, leading to pyroptosis.

Membrane Tension Drives Opening of NINJ1 Lesions in Dying Cells

This study shows membrane tension drives NINJ1 filament opening, causing cell lysis, and explains why NINJ2 fails to form lesions.

Insights into Gasdermin D activation from the crystal structure of its C-terminal domain

The paper reports the crystal structure of GSDMD's C-terminal domain to analyze activation determinants and interactions with the N-terminal domain.