Sang‐Hun Lee

Transplanting human hypothalamic neural stem cells into aged mice improves metabolic, physical, and cognitive function via the SNS/eNAMPT axis.

This study shows JMJD3 deficiency in midbrain dopamine neurons reduces dopamine levels and worsens chronic inflammatory pain.

This study shows that premature MeCP2 expression disrupts midbrain dopamine neuron subtype specification by interfering with NURR1 transactivation and TET1-mediated demethylation in NPCs.

This study shows G9a/GLP methyltransferases inhibit autophagy by methylating and degrading ATG12, but their degradation under stress allows ATG12 accumulation and autophagy activation.

This study corrects an ABCD1 mutation in ALD patient-derived iPSCs using CRISPR/Cas9 and homology-directed repair, restoring normal protein expression but not fully correcting metabolic issues.