Avs2 drives non-canonical tetrameric assembly of trypsin-like domain for anti-phage defense
Lijie Guo, Pingping Huang, Wenhui Liu…·Meirong Chen
The paper elucidates the molecular mechanism of the Avs2-trypsin-MBL system, revealing how phage terminase recognition triggers tetramerization and activation of the system for anti-phage defense.