Lijie Guo

The paper elucidates the molecular mechanism of the Avs2-trypsin-MBL system, revealing how phage terminase recognition triggers tetramerization and activation of the system for anti-phage defense.

This study identifies a trypsin-MBL module as a bacterial immune effector that uses proteolytic activation to enable DNase activity against invading nucleic acids while preventing self-toxicity.

This study reveals the mechanism of the DdmDE system in Lactobacillus casei, showing how it degrades plasmids through a guided helicase-nuclease activity.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.