Jean‐Baptiste Cazier

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

The paper identifies chromatin priming elements that activate before gene expression during hematopoietic differentiation and shows their role in developmental timing.

The paper identifies thousands of cell stage-specific enhancers that drive hematopoietic specification by responding to cytokine signals and transcription factors.

This study shows that transposable elements contribute to the transcriptome of human pluripotent stem cells by being spliced into coding and non-coding transcripts, affecting gene expression and generating novel peptides.