Isaac A. Babarinde

The paper identifies a HNRNPU-CHD2 RNA-processing axis linked to neurodevelopmental disease by showing HNRNPU depletion causes splicing changes in CHD2 that may lead to nonsense-mediated decay.

This study shows transposable elements contribute significantly to 3D genome structure by mediating chromatin contacts through specific transcription factors.

This study examines TE expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages, revealing lineage-specific TE expression patterns and chromatin associations.

This study examines how sequencing depth affects transcript assembly accuracy in human genomes, finding that noncoding transcripts are more sensitive to depth than coding ones.

This study identifies a quiescent-like state in arrested IVF embryos and shows that modulating metabolic pathways can rescue the arrest.

The paper develops a single-cell TE analysis pipeline, scTE, and shows TEs are dynamically expressed in various cell states and can be used for cell type discrimination.

This study shows that transposable elements contribute to the transcriptome of human pluripotent stem cells by being spliced into coding and non-coding transcripts, affecting gene expression and generating novel peptides.