Ana Rio‐Machín

DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

Non-coding mutations at enhancer clusters contribute to pancreatic ductal adenocarcinoma

The paper identifies non-coding mutations in enhancer clusters associated with pancreatic ductal adenocarcinoma and validates their functional impact using computational and experimental methods.

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

The paper identifies two distinct subgroups of KMT2A-rearranged AML using phosphoproteomics and shows different drug response profiles.

A dual role for the RNA helicase DHX34 in NMDand pre-mRNA splicing and its function inhematopoietic differentiation

This study identifies DHX34 as a dual regulator of NMD and pre-mRNA splicing, showing its role in hematopoietic differentiation and disease.

Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukemia

The paper identifies endogenous retroviruses (ERVs) as a source of oncogenic enhancers in acute myeloid leukemia (AML) and shows their role in altering gene expression and promoting cell growth.