Andrew P. Hutchins

A candidate HNRNPU-CHD2 RNA-processing axis in neurodevelopmental disease

The paper identifies a HNRNPU-CHD2 RNA-processing axis linked to neurodevelopmental disease by showing HNRNPU depletion causes splicing changes in CHD2 that may lead to nonsense-mediated decay.

SALL2 constrains TEAD4 by maintaining repressive chromatin to restrict trophectoderm identity

This study shows SALL2 restricts trophectoderm identity by maintaining repressive chromatin at TEAD4-bound loci, preventing TE lineage commitment in human pluripotent stem cells.

Cellular type is a major determinant of R-loop genomic distribution

The paper shows that cellular type significantly affects R-loop genomic distribution, with only 26% of peaks overlapping between different cell lines.

Dissecting the Contribution of Transposable Elements to Interphase Chromosome Structure

This study shows transposable elements contribute significantly to 3D genome structure by mediating chromatin contacts through specific transcription factors.

Transposable Element Expression and Sub-cellular Dynamics During hPSC Differentiation to Endoderm, Mesoderm, and Ectoderm Lineages

This study examines TE expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages, revealing lineage-specific TE expression patterns and chromatin associations.

Thioredoxin-1 inhibits granulosa cell ferroptosis to rescue ovarian aging through mitophagy-dependent activation of BNIP3L

This study shows that Thioredoxin-1 prevents granulosa cell ferroptosis by promoting mitophagy, thereby improving ovarian aging and fertility in mice.

Multimodal brain cell atlas across the adult macaque lifespan

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

The effects of sequencing depth on the assembly of coding and noncoding transcripts in the human genome

This study examines how sequencing depth affects transcript assembly accuracy in human genomes, finding that noncoding transcripts are more sensitive to depth than coding ones.

Human embryos arrest in a quiescent-like state characterized by metabolic and zygotic genome activation problems

This study identifies a quiescent-like state in arrested IVF embryos and shows that modulating metabolic pathways can rescue the arrest.

Unveiling transposable element expression heterogeneity in cell fate regulation at the single-cell level

The paper develops a single-cell TE analysis pipeline, scTE, and shows TEs are dynamically expressed in various cell states and can be used for cell type discrimination.

Transposable Element-Gene Splicing Modulates the Transcriptional Landscape of Human Pluripotent Stem Cells

This study shows that transposable elements contribute to the transcriptome of human pluripotent stem cells by being spliced into coding and non-coding transcripts, affecting gene expression and generating novel peptides.

Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing

Single cell RNA sequencing identifies two reprogramming branches in mouse fibroblasts, with Dppa5a marking pluripotent cells and IFN-gamma inhibiting the transition.