Molecular BiologybioRxivPreprint
Rescue from pyridostatin-stabilized telomeric G-quadruplexes by DNA cleavage and microhomology-mediated end joining
Samah Matmati, Satyajeet Rao, Joachim Lingner
This study shows pyridostatin stabilizes telomeric G-quadruplexes, inhibiting lagging strand replication, which is overcome by FEN1/DNA2 cleavage and MMEJ repair, suggesting potential for anti-cancer therapies.
DOI 10.1101/2025.11.25.690390