Joachim Lingner

Medulloblastoma-Associated KBTBD4 Mutations Disrupt PP2A-A Orphan Quality Control

This study identifies PP2A-A as a target of CRL3KBTBD4, showing that KBTBD4 mutations disrupt PP2A quality control and contribute to medulloblastoma by altering phospho-dependent signaling.

Rescue from pyridostatin-stabilized telomeric G-quadruplexes by DNA cleavage and microhomology-mediated end joining

This study shows pyridostatin stabilizes telomeric G-quadruplexes, inhibiting lagging strand replication, which is overcome by FEN1/DNA2 cleavage and MMEJ repair, suggesting potential for anti-cancer therapies.

TERRA R-loops trigger a switch in telomere maintenance towards break-induced replication and PrimPol-dependent repair

This study shows that TERRA R-loops induce ALT-like telomere repair through BIR and PrimPol-dependent mechanisms in telomerase-expressing cells.

Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression

Spotiflow improves spot detection in microscopy images using deep learning, achieving subpixel accuracy and efficiency across diverse datasets.

Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA Repair

This study shows that human POT1 prevents telomere instability caused by homology directed repair through proteomic and genetic analyses.

SMCHD1 Promotes ATM-dependent DNA Damage Signaling and Repair of Uncapped Telomeres

This study shows SMCHD1 is required for ATM-dependent DNA damage signaling and repair of uncapped telomeres, with its depletion reducing telomere fusions in TRF2-depleted cells.

RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility

The paper identifies RADX as a telomere-binding protein that suppresses telomere fragility by counteracting RAD51 binding, alongside POT1.