BiochemistrybioRxivPreprint
Detergent selection as a determinant of lysate melting behavior and drug-target hit-calling in thermal stability proteomics
Catherine M Sniezek, Veronika A. Glukhova, Christopher Schmitz…·Devin K. Schweppe
This study evaluates how detergent selection and timing affect thermal stability proteomics results, finding that DDM improves detection of some drug-target interactions but may obscure others.
DOI 10.64898/2026.05.28.728510